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NFL Week 10 betting guide: Odds, key matchups, stats & trends, injury report for every game

Sporting News — customerservice@sportingnews.com (Sporting News)

The NFL Week 10 betting guide highlights each and every game with plenty of betting analysis to chew on. We look at opening NFL odds, market movements, injury reports and various key stats and betting trends and more in an effort to provide insight to NFL bettors in their handicapping endeavors. 

MORE: Get the latest NFL odds & betting advice at Sportsbook Review

Los Angeles Chargers vs. Oakland Raiders 

  • Thursday, Nov. 7, 2019, 8:20 p.m. ET 
  • RingCentral Coliseum, Oakland  
  • TV Broadcast: FOX/NFL 
  • Opening NFL Odds: PK / 47.5
  • Season Record: Chargers (4-5-0) vs Raiders (4-4-0) 

The Chargers are on the move and the Raiders are coasting under the radar. The Chargers are coming off an upset over the Packers at home, stacking back-to-back wins over the last few weeks. The Raiders edged the Lions in a shootout at the Coliseum to improve to 3-1 SU at home and bounce back from a loss to the Texans in Week 8. 

All told, these teams appear evenly matched and the Chargers are nipping at the Raiders’ heels in the AFC West standings. Both have seen close games go either way this season. So, it’s no surprise bookmakers pegged this tilt on a PK line at open doors all the while setting the total to 47.5. 

Interestingly, the NFL line is on the move in favor of the Chargers (they’re currently laying anywhere from -1 to -1.5 on the NFL odds board. The total has jumped up to 48.5 and 49, depending on your choice sportsbook. 

The latter isn’t surprising given the Raiders have already been involved in several shootouts this season (last week’s 31-24 win over the Lions is case and point, marking the fifth game to crack the OVER in their last 6). Rivers can air out the ball with the best of them even though we’ve not seen much of it this season, but that trend might change seeing as the Chargers have made changes to their offensive staff. A possible play on the OVER for this game looks to be a smart NFL pick. 

NFL Betting Trends: 

— Raiders are 6-1 ATS in their last 7 games at home 
— Chargers are 3-4-2 ATS in their last 9 games 
— The total has gone UNDER in 5 of LA Chargers' last 5 games when playing Oakland 
— The total has gone UNDER in 7 of LA Chargers' last 8 games 

Key Injuries: 

LAC – RB Justin Jackson (Calf), LB Denzel Perryman (Knee) and T Sam Tevi (Knee) are all questionable for TNF. 

OAK – DT Johnathan Hankins (Foot), OL Andre James (Ankle) and S Erik Harris (Illness) are all questionable for TNF. RB Josh Jacobs (Shoulder) is probable for TNF. 

MORE: Follow the latest trends for Chargers vs. Raiders

Detroit Lions vs. Chicago Bears  

  • Sunday, Nov. 10, 2019, 1 p.m. ET
  • Soldier Field, Chicago 
  • TV Broadcast: CBS 
  • Opening NFL Odds: Bears -3 / 43.5 
  • Season Record: (Lions (3-4-1) vs Bears (3-5-0) 

The NFC North tilt between the frustrating Lions and woeful Bears features on Week 10’s NFL betting card. How the Bears opened donating a field goal is beyond comprehension though.

The Bears offense is MIA, Mitch Trubisky is clueless and their once vaunted defense has gone walkabout. Matt Nagy looks to be running out of ideas as well and his play calling leaves much to be desired. The Bears are 1-3 SU and ATS at home this season. They are riding a four-game losing streak and propping up the NFC North table to boot. How the mighty have fallen. 

The Lions continue to suffer defensive issues as evinced in their 31-24 loss to the Raiders, but Matt Stafford is enjoying a stellar season on the stats sheet. The Lions are 1-2-1 SU and 2-2 ATS on the road this season. If they can stop shooting themselves in the foot they have a punter’s chance. 

Since open doors, the Lions have come down to -2.5 on the NFL odds board at several sports venues but given Mitch Trubisky isn’t cutting it this still looks like a lot of points to risk on the Bears. Fading the Bears and taking the Lions at +3, which is still available at various sports betting venues, looks to be the better play. 

NFL Betting Trends: 

— Lions are 4-4 ATS in their last 8 games 
— Lions are 9-3 SU in their last 12 games when playing Bears 
— Bears are 2-6 ATS in their last 8 games 
— The total has gone OVER in 5 of Detroit's last 6 games  
— The total has gone UNDER in 6 of Chicago's last 7 games at home 
— The total has gone UNDER in 10 of Chicago's last 13 games 

Key Injuries: 

DET – G Joe Dahl (Ankle) and DL De’Shawn Hand (Elbow) are both questionable for week 10; TE T.J. Hockenson (Back) is probable for week 10. 

CHI – DB Deon Bush (Illness) and NT Eddie Goldman (Thigh) are both questionable for week 10. 

MORE: Follow the latest trends for Lions vs. Bears

Baltimore Ravens vs. Cincinnati Bengals 

  • Sunday, Nov. 10, 2019, 1 p.m. ET
  • Paul Brown Stadium, Cincinnati 
  • TV Broadcast: CBS 
  • Opening NFL Odds: Ravens -11.5 / 46 
  • Season Record: Ravens (6-2-0) vs Bengals (0-8-0) 

The Ravens just dethroned the AFC high-flyers New England Patriots in a shocking 37-20 win in Sunday Night Football. What was even more shocking was the manner in which they did, with such verve and swagger. At one point, it looked like Lamar Jackson and the Ravens would runaway with the game entirely.  

Tale told,  it’s no surprise that oddsmakers went to press with a whopping double-digit spread for their upcoming clash against the lone winless team in the NFL, Cincinnati Bengals. The 0-8 SU Bengals cut a sad figure. What’s more, the Bengals have benched Andy Dalton in favor of backup Ryan Finley, an announcement made during the bye week.  

Curiously, the NFL line for this game is on the move but not in favor of the Ravens. Since open doors, the point spread has trimmed down to a low of Ravens -9.5 thanks to early betting taking the points with the Bengals.  

For those on board with the Ravens playing the waiting game to see if you get a better number is an option, but if you like them now grab them at -9.5 while you can because this NFL line could go back up to double-digits later in the week. 

NFL Betting Trends: 

— Ravens are 4-1 SU in their last 5 games on the road 
— Ravens are 4-1 SU in their last 5 games  
— Bengals are 6-1 SU in their last 7 games when playing at home against Ravens 
— Bengals are 5-1 ATS in their last 6 games when playing Ravens 

Key Injuries: 

BAL — no new injuries currently listed 

CIN — DT Ryan Glasgow (Knee) is on I-R; G Alex Redmond (Ankle) and CB Darqueze Dennard (Hamstring) are both questionable for week 10. 

MORE: Follow the latest trends for Ravens vs. Bengals

Buffalo Bills vs. Cleveland Browns 

  • Sunday, Nov. 10, 2019, 1 p.m. ET
  • FirstEnergy Stadium, Cleveland 
  • TV Broadcast: CBS 
  • Opening NFL Odds: Browns -3 / 41.5 
  • Season Record: Bills (6-2-0) vs Browns (2-6-0) 

Of all the NFL lines on Week 10’s betting card, this is the head scratcher of the lot. How the Browns are giving a field goal to the Bills is madness.  

Yes, yes, Kareem Hunt might feature in this game for the first time since being suspended and dumped from Kansas City, but Baker Mayfield is no Mahomes. A player is only as good as his quarterback is and the verdict on Mayfield at the moment is that he’s pretty bad.  

The Browns are a mess, lacking in confidence and cohesion. The offense is wholly off colour and form and the defense is nothing to write home about. The Browns have lost four on the trot and if the Bengals were not in worse form, the Browns would be propping up the AFC North. So much for being Super Bowl contenders. 

The Browns are winless in the Dawg Pound as well and 0-3 ATS, which includes a -13.7 losing margin on average and a -14.5-point differential versus the spread on average. The Bills are a perfect 3-0 ATS on the road with a 7.3 winning margin on average and a +9-point differential versus the spread on average. 

Love or hate the Bills, they’re undeniably the better team going into this pivotal AFC clash on Sunday. Grab the Bills +3 while you can because this line is the likeliest to be bet down by the public, if not flip altogether. 

NFL Betting Trends: 

— Bills are 5-3 ATS in their last 8 games 
— Bills are 5-1 ATS in their last 6 games on the road 
— Browns are 2-6 ATS in their last 8 games 
— The total has gone UNDER in 5 of Buffalo's last 5 games on the road 
— The total has gone UNDER in 16 of Cleveland's last 24 games at home 
— The total has gone UNDER in 4 of Cleveland's last 6 games when playing Buffalo 

Key Injuries: 

BUF – LB Maurice Alexander (Knee) is listed as questionable for week 10. 

CLE – T Greg Robinson (Ankle), DE Olivier Vernon (Lower Body) and TE Ricky Seals-Jones (Knee) are all listed as questionable for week 10; S Eric Murray (Knee) is out indefinitely. 

MORE: Follow the latest trends for Bills vs. Browns

Kansas City Chiefs vs. Tennessee Titans 

  • Sunday, Nov. 10, 2019, 1 p.m. ET 
  • Nissan Stadium, Nashville 
  • TV Broadcast: CBS 
  • Opening NFL Odds: Chiefs -3.5 / 48.5
  • Season Record: Chiefs (6-3-0) vs Titans (4-5-0) 

Most sports betting platforms are holding out with the NFL line for this game given the uncertainties that surround Patrick Mahomes and his status for Week 10. A few sportsbooks have posted the NFL line however and it sits around Chiefs -4, which practically factors Matt Moore as the starter.   

If you’re on board with the Chiefs regardless of who the starter is, grabbing this number now could prove dividends because it’s safe to assume this line is likely to jump up significantly if Mahomes is confirmed as the starter. Moore led the Chiefs to victory over the Vikings.

Even with Moore, the Chiefs are a much better team than the Titans are with either Marcus Mariota or Ryan Tannehill. The latter put in a couple of wins for the Titans but last week in the loss to the Panthers some of the issues that plagued him in Miami cropped up.  

NFL Betting Trends: 

— Chiefs are 5-1 SU in their last 6 games on the road 
— Chiefs are 4-1 ATS in their last 5 games when playing on the road against Titans 
— Titans are 18-6 SU in its last 24 games at home 
— Titans are 3-5-1 ATS in their last 8 games 
— The total has gone OVER in 4 of Tennessee's last 5 games when playing at home against Kansas City 
 
Key Injuries: 

KC – QB Patrick Mahomes (Ankle/Knee), G Laurent Duvernay-Tardiff (Ankle) and DE Alex Okafor (Ankle) are all questionable for week 10; OL Greg Senat (Undisclosed) is on I-R; DE Frank Clark (Neck) is out indefinitely. 

MORE: Follow the latest trends for Chiefs vs. Titans

Atlanta Falcons vs. New Orleans Saints  

  • Sunday, Nov. 10, 2019, 1 p.m. ET
  • Mercedes-Benz Stadium, New Orleans 
  • TV Broadcast: FOX 
  • Opening NFL Odds: Saints -14 / 51 
  • Season Record:  Falcons (1-7-0) vs Saints (7-1-0) 

The woeful Falcons take on divisional foes Saints in a battle of the worst versus the best of the NFC South. Somehow, Dan Quinn and his staff survived the bye week which can’t be a good thing for Atlanta’s chances if the first eight weeks of the season are anything to go by. Not least when considering the Saints are also coming off a bye week, Atlanta’s chances look a lot more grim with the prospect of a well-rested Drew Brees to contend with. 

Fittingly, bookmakers installed this game on a whopping -14 point spread at open doors. It’s the biggest spread the Falcons have faced this season, but they’re 0-4 ATS on the road with a 10.2 losing margin on average and a -8.9 differential versus the spread on average. The Saints, meanwhile, are 3-1 ATS at home with an 8.2 winning margin on average and a +3.4 differential versus the spread. 

Overall, the Saints are the most successful team against the spread this season behind a 6-2 ATS mark, which includes a 4.9 winning margin on average and a +4.1 differential versus the spread. In Week 6, Drew Brees led the Saints in a 31-9 win over the Cardinals to cover the -12.5 closing spread. 

NFL Betting Trends: 

— Falcons are 2-6 ATS in their last 8 games 
— Saints are 5-0 ATS in their last 5 games  
— Saints are 5-0 SU in their last 5 games 
— The total has gone OVER in 4 of Atlanta's last 5 games on the road 
— The total has gone UNDER in 4 of New Orleans’ last 8 games 

Key Injuries: 

ATL – QB Matt Ryan (Ankle) is probable for week 10; G James Carpenter (Knee) and DE John Cominsky (Ankle) are both questionable for week 10. 

NO – no new injuries currently listed 

MORE: Follow the latest trends for Chargers vs. Raiders

New York Giants vs. New York Jets 

  • Sunday, Nov. 10, 2019, 1 p.m. ET 
  • MetLife Stadium, East Rutherford 
  • TV Broadcast: FOX 
  • Opening NFL Odds: Giants -2.5 / 43 
  • Season Record: Giants (2-7-0) vs Jets (1-7-0)

The NY Giants and NY Jets collide at MetLife Stadium for an inter-conference showdown that features two of the league’s worst teams. Most recently, the Giants lost to the Cowboys on Monday Night Football at MetLife Stadium, and the Jets lost to the Miami Dolphins (yup, not a typo) in what was a horrendous performance by Sam Darnold that had even his teammates giving him an earful on the field. 

Given recent performance it’s hard to feel confident about either team — the Giants are riding a five-game losing streak while the Jets are riding a three-game losing streak. Yet, somehow, the Giants are laying -2.5 on the NFL odds board. 

Seeing as neither team looks to have any momentum, confidence or cohesion on either side of the ball, this is perhaps one of the matches NFL bettors might consider playing the waiting game. See which way the needle moves before pulling the trigger for Week 10 NFL picks
 
NFL Betting Trends: 

— NY Giants are 5-1 SU in their last 6 games when playing NY Jets 
— NY Giants are 3-6 ATS in their last 8 games 
— NY Jets are 1-3-1 ATS in their last 5 games when playing at home against NY Giants 
— NY Jets are 2-6 ATS in their last 8 games 
— The total has gone OVER in 5 of NY Giants' last 5 games on the road 
— The total has gone OVER in 4 of NY Jets' last 6 games 

Key Injuries: 

NYG – TE Evan Engram (Foot) is listed as questionable for week 10. 

NYJ – RB Le’Veon Bell (Knee), DL Steve McLendon (Neck) and S Jamal Adams (Head) are all questionable for week 10. 

MORE: Follow the latest trends for Giants vs. Jets

Arizona Cardinals vs. Tampa Bay Buccaneers 

  • Sunday, Nov. 10, 2019, 1 p.m. ET
  • Raymond James Stadium, Tampa 
  • TV Broadcast: FOX 
  • Opening NFL Odds: Bucs -6 / 53.5
  • Season Record: Cardinals (3-5-1) vs Bucs (2-6-0) 

Vegas lookahead NFL lines had the Bucs tipped as the whopping -6 home chalk for this week 10 clash, but following Arizona’s commendable account against the San Francisco 49ers mainly, the NFL line plummeted to the Bucs laying just -4.5.  

Jameis Winston and the Bucs put up a fight in Seattle but fell on the losing side of 40-34 shootout in overtime. The loss marked the fifth straight loss for the Bucs since beating the Rams in stellar fashion in week 4. 

The Bucs are 0-2 ATS at home with a 7.5-point losing margin on average and a -10.5 differential versus the spread. The Cardinals are 3-1 ATS on the road with a 4.8 losing margin on average and a +3.2 differential versus the spread. 

To all intents and purposes, this is a bit of a tossup for Week 10 NFL picks. For those backers that fancy the Cardinals taking the points now is a smart play. For those that fancy the Bucs play the waiting game to get a better line potentially. 

NFL Betting Trends: 

— Cardinals are 4-1 ATS in their last 5 games on the road 
— Cardinals are 4-1 ATS in their last 5 games  
— Bucs are 2-6 ATS in their last 8 games 
— The total has gone OVER in 5 of Tampa Bay's last 5 games  
— The total has gone UNDER in 8 of Tampa Bay's last 11 games when playing Arizona 

Key Injuries: 

ARI – LB Terrell Suggs (Knee) and DT Clinton McDonald (Stinger) are both questionable for week 10. 

TB – TE Antony Auclair (Toe), CB Carlton Davis (Hip), LB Carl Nassib (Groin) and LB Anthony Nelson (Hamstring) are all questionable for week 10. 

MORE: Follow the latest trends for Cardinals vs. Buccaneers

Miami Dolphins vs. Indianapolis Colts 

  • Sunday, Nov. 10, 2019, 4:05 p.m. ET  
  • Lucas Oil Stadium, Indianapolis 
  • TV Broadcast: CBS 
  • Opening NFL Odds: Colts -14.5 / 44
  • Season Record: Dolphins (1-7-0) vs Colts (5-3-0) 

The Dolphins finally crack the win column with a franchise satisfying win over Adam Gase and the NY Jets. It was such a massive accomplishment head coach Brian Flores got the Gatorade shower.  

The Colts, meanwhile, suffered a disappointing loss to the Pittsburgh Steelers on the road in week 9. More importantly, Jacoby Brissett suffered an injury caused by his own teammate colliding into him in the pocket. It remains to be seen whether Brissett will start on Sunday or if 
Brian Hoyer takes over at center. 

While the Dolphins began the season as the quintessential punching bag of the NFL, recent weeks have shown positive signs. Namely, the Dolphins have covered four straight games.  As such, since open doors the NFL line for this tilt dropped from Colts -14.5 to -10 as early bettors grabbed the points with the Dolphins. 

For those looking to bet this game, play the waiting game especially if you’re on board with the Dolphins against the spread. Reports from Colts look favorable towards Brissett starting in this game, in which case this NFL line might jump out again.  

NFL Betting Trends: 

— Dolphins are 8-1 ATS in their last 9 games when playing on the road against Colts 
— Dolphins are 4-1 ATS in their last 5 games  
— Colts are 9-1 SU in their last 10 games at home 
— Colts are 6-1 SU in their last 7 games when playing Dolphins 

Key Injuries: 

MIA – RB Mark Walton (Suspension) not eligible before week 14; WR Preston Williams (Knee) is out for the season. 

IND – WR Parris Campbell (Hand) is out indefinitely; QB Jacoby Brissett (Knee) and C Ryan Kelly (Stinger) are both questionable for Sunday. 

MORE: Follow the latest trends for Dolphins vs. Colts

Carolina Panthers vs. Green Bay Packers 

  • Sunday, November 10, 2019, 4:25 PM EST  
  • Lambeau Field, Green Bay 
  • TV Broadcast: FOX 
  • Opening NFL Odds: Packers -6 / 48
  • Season Record: Panthers (5-3-0) vs Packers (7-2-0) 

Although the Green Bay Packers are coming off one of the worst losses in 2019, they remain significant favorites on the NFL odds board for their upcoming date with the Carolina Panthers. It’s a home game and Lambeau Field is a tough environment for the best of teams.  

However, the public seems to be high on the Panthers as the line is moving in their favor. The Panthers are down to +5 with most sports betting platforms, thanks largely down to early money taking the points with Carolina. 

If this betting trend continues, this NFL line could shrink further. In fact, some sportsbooks have come down to Packers laying just -4.5. So, for those backers looking to shade the Panthers on their Week 10 NFL picks, buy now before the line shrinks further. 

For those on board with the Packers, play the waiting game to see if you can get a better line such as -4 (without the pesky hook). Panthers are 2-1 ATS on the road with a 4.7 losing margin on average while the Packers are 3-2 ATS at home with a 5.6 winning margin on average. 

NFL Betting Trends: 

— Panthers are 5-1 ATS in their last 6 games  
— Packers are 6-3 ATS in their last 9 games 
— The total has gone OVER in 5 of Carolina's last 5 games when playing Green Bay 
— The total has gone OVER in 5 of Green Bay's last 6 games when playing at home against Carolina 

Key Injuries: 

CAR – QB Cam Newton (Foot) is on I-R; CB James Bradberry (Groin) and LB Mario Addison (Personal) are both listed as questionable for week 10. 

GB – no new injuries listed. 

MORE: Follow the latest trends for Panthers vs. Packers

Los Angeles Rams vs. Pittsburgh Steelers 

  • Sunday, Nov. 10, 2019, 4:25 p.m. ET
  • Heinz Field, Pittsburgh 
  • TV Broadcast: FOX 
  • Opening NFL Odds: Rams -3.5 / 45.5
  • Season Record: Rams (5-3-0) vs Steelers (4-4-0) 

A few weeks ago, few would have predicted a competitive matchup with the Rams favored by just above a field goal would be possible. Yet, with the Steelers clawing their way back into contention that’s exactly what we have before us for this intriguing week 10 clash.  

The Rams have the advantage of a bye week and should come into this game well rested. However, Heinz Field is a tough environment as evinced in recent weeks. The Steelers are 3-2 SU and ATS at home, which includes a 6.8 winning margin on average. The Rams, however, are 3-1 SU and 4-0 ATS on the road this season, which includes a 9-point winning margin on average and a +9-point differential versus the spread. 

Betting is split nearly down the middle between this pair as one would expect with the Rams edging the Steelers ever so slightly. That has caused the line to go up to a 4-point spread at several outlets. For those backers that are buying what the Steelers are selling, grab the Steelers at +4, which is available at several sportsbooks. These plucky underdogs could have a few more surprises up their sleeve and their defense is nothing to scoff at. 

NFL Betting Trends: 

— LA Rams are 5-0 ATS in their last 5 games on the road 
— LA Rams are 5-1 SU in their last 6 games on the road 
— Steelers are 5-1 SU in their last 6 games when playing at home against LA Rams 
— Steelers are 4-1 SU in their last 5 games 
 
Key Injuries: 

LAR – WR Brandon Cooks (Concussion) is out indefinitely. 

PIT – RB Trey Edmunds (Ribs) is listed as questionable for week 10. 

MORE: Follow the latest trends for Rams vs. Steelers

Minnesota Vikings vs. Dallas Cowboys 

  • Sunday, Nov. 10, 2019, 8:20 p.m. ET
  • AT&T Stadium, Arlington 
  • TV Broadcast: NBC 
  • Opening NFL Odds: Cowboys -3 / 47
  • Season Record:  Vikings (6-3-0) vs Cowboys (5-3-0) 

The Dallas Cowboys improve to 5-3 SU behind a solid 37-18 win over the NY Giants on the road in Monday Night Football. It marked their second straight win since snapping a three-game losing streak at the expense of the Philadelphia Eagles. The Cowboys are 2-3 SU in their last five games and 3-1 SU at home. 

The Vikings succumbed to their first loss in five games, losing to the Chiefs on the road 26-23. The Vikings are 4-1 SU in their last five games and 2-3 SU and ATS on the road this season.  

Vegas lookahead lines opened this game with the Cowboys laying -3 on the NFL odds board. 

Since open doors, this line hasn’t moved much although early betting shows the Vikings are getting most of the early wagers. If this trend continues, it’s likely the line will move against Minnesota. For those on board with Kirk Cousins, taking the Vikings now at +3 could be the smart play. 

NFL Betting Trends: 

— Vikings are 9-1 ATS in their last 10 games when playing Cowboys 
— Cowboys are 8-1 SU in their last 9 games at home 
— The total has gone UNDER in 4 of Minnesota's last 5 games when playing Dallas 
— The total has gone OVER in 5 of Dallas' last 8 games  

Key Injuries: 

MIN — WR Adam Thielen (Hamstring) is listed as questionable for week 10. 

DAL – S Jeff Heath (Leg) is listed as questionable for week 10. 

MORE: Follow the latest trends for Vikings vs. Cowboys

Seattle Seahawks vs. San Francisco 49ers  

  • Monday, Nov. 11, 2019, 8:15 p.m. ET  
  • Levi’s Stadium, Santa Clara 
  • TV Broadcast: ESPN 
  • Opening NFL Odds: Niners -7 /45 
  • Season Record: Seahawks (7-2-0) vs Niners (8-0-0) 

This is the marquee matchup of the week and fitting end to week 10 as the Seahawks and Niners collide in Monday Night Football. The Seahawks-Niners rivalry hasn’t been what it used to be in recent years, but with the Niners remaining the lone undefeated team in the NFL, it’s possible this NFC West rivalry could light up again. 

Vegas lookahead lines tipped this tilt with the Niners laying a touchdown on the NFL odds board and since early markets opened it has experienced marked movement. The Niners are currently sitting pretty anywhere from -6 to -6.5, largely down to early money going towards the Seahawks plus the points. Seahawks are coming off a shootout win over the Bucs at CenturyLink Field, in which Russell Wilson had a standout performance and practically carried his team on his shoulders to victory. 

The Niners have the advantage with added rest having played on Thursday Night Football against the Arizona Cardinals. Jimmy Garoppolo may not have tapped into Russell Wilson’s level, but he carried the Niners to victory by shredding the Cardinals through the air. Thereby, proving the Niners offense was more than just a run-heavy-minded weapon. 

It’s the Niners’ second NFC West showdown in as many weeks and third this season after beating both the Rams and Cardinals It’s the first meeting of the season against the Seahawks with top position on the line.  

To be fair, with everything that is at stake, this matchup could go either way. For those looking to back Seattle, taking the points now is probably the better play. For those looking to bank on the Niners, play the waiting game. If the trend towards the Seahawks continues, it’s likely the NFL line will be shaved some more before Monday’s kick-off. 

NFL Betting Trends: 

— Seahawks are 10-1 SU in their last 11 games when playing 49ers 
— Seahawks are 5-1 SU in their last 6 games  
— 49ers are 5-0 SU in their last 5 games  
— 49ers are 5-1 SU in their last 6 games at home 

Key Injuries: 

SEA – TE Luke Williams (Ribs) is probable for MNF; WR Josh Gordon (Acquired) is questionable for MNF. 

SF – TE George Kittle (Knee) and DL Arik Armstead (Throat) are both questionable for MNF. LB Kwon Alexander (Pectoral) is out for the season.  

MORE: Follow the latest trends for Seahawks vs. 49ers